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Genomic views of STAT function in CD4+ T helper cell differentiation.

Authors
  • O'Shea, John J
  • Lahesmaa, Riitta
  • Vahedi, Golnaz
  • Laurence, Arian
  • Kanno, Yuka
Type
Published Article
Journal
Nat Rev Immunol
Publisher
Nature Publishing Group
Publication Date
Apr 01, 2011
Volume
11
Issue
4
Pages
239–250
Identifiers
DOI: 10.1038/nri2958
PMID: 21436836
Source
Medline
License
Unknown

Abstract

Signal transducer and activator of transcription (STAT) proteins are well known for their essential roles in transmitting cytokine-mediated signals and specifying T helper (T(H)) cell differentiation. Recent technological advances have revealed that STAT proteins have broad and complex roles in gene regulation and epigenetic control, including important roles as functional repressors. However, the challenge of how to link signal transduction, nucleosome biology and gene regulation remains. The relevance of tackling this problem is highlighted by genome-wide association studies that link cytokine signalling and STATs to various autoimmune or immune deficiency disorders. Defining exactly how extrinsic signals control the specification and plasticity of T(H) cells will provide important insights and perhaps therapeutic opportunities in these diseases.

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