Genomic rearrangement screening of the BRCA1 from seventy Iranian high-risk breast cancer families.

Maryam Sedghi; Elham Esfandiari; Esmat Fazel-Najafabadi; Mansoor Salehi; Abbas Salavaty; Shirin Fattahpour; Leila Dehghani; Nayerossadat Nouri; Fariborz Mokarian

doi:10.4103/1735-1995.193167

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Genomic rearrangement screening of the BRCA1 from seventy Iranian high-risk breast cancer families.

Authors

Sedghi, Maryam¹
Esfandiari, Elham²
Fazel-Najafabadi, Esmat²
Salehi, Mansoor³
Abbas Salavaty²
Fattahpour, Shirin²
Dehghani, Leila⁴
Nouri, Nayerossadat¹
Mokarian, Fariborz⁵

¹ Medical Genetics Laboratory, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran; Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of
² Medical Genetics Laboratory, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Medical Genetics Laboratory, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran; Division of Genetics and Molecular Biology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
⁴ Department of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Isfahan Neurosciences Research Center, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
⁵ Department of Oncology, Isfahan University of Medical Sciences, Isfahan, Iran.

Type

Published Article

Journal

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

Publication Date

Jan 01, 2016

Volume

21

Pages

95–95

Identifiers

DOI: 10.4103/1735-1995.193167

PMID: 28163741

Source

Medline

Keywords

License

Unknown

Abstract

Although our data confirm that LGRs in BRCA1 comprise a relatively small proportion of mutations in hereditary breast cancer in the Iranian population, MLPA analysis might be considered for screening of LGRs in high-risk individuals. It is worth to note that our results are consistent with previous studies in various Asian and European countries.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 02/24/2018 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/28163741

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