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Genomic perspective on the photobiology of Halobacterium species NRC-1, a phototrophic, phototactic, and UV-tolerant haloarchaeon

Authors
  • DasSarma, Shiladitya1
  • Kennedy, Sean P.1
  • Berquist, Brian1
  • Victor Ng, Wailap2
  • Baliga, Nitin S.2
  • Spudich, John L.3
  • Krebs, Mark P.4
  • Eisen, Jonathan A.5
  • Johnson, Carl H.6
  • Hood, Leroy2
  • 1 University of Maryland Biotechnology Institute, Center of Marine Biotechnology, Baltimore, MD, 21202, USA , Baltimore
  • 2 Institute for Systems Biology, Seattle, WA, 98105, USA , Seattle
  • 3 University of Texas Medical School, Department of Microbiology and Molecular Genetics, Houston, TX, 77030, USA , Houston
  • 4 Illinois State University, Department of Biological Sciences, Normal, IL, 61790, USA , Normal
  • 5 The Institute of Genomic Research, Rockville, MD, 20850, USA , Rockville
  • 6 Vanderbilt University, Department of Biological Sciences, Nashville, TN, 37235, USA , Nashville
Type
Published Article
Journal
Photosynthesis Research
Publisher
Kluwer Academic Publishers
Publication Date
Oct 01, 2001
Volume
70
Issue
1
Pages
3–17
Identifiers
DOI: 10.1023/A:1013879706863
Source
Springer Nature
Keywords
License
Yellow

Abstract

Halobacterium species display a variety of responses to light, including phototrophic growth, phototactic behavior, and photoprotective mechanisms. The complete genome sequence of Halobacterium species NRC-1 (Proc Natl Acad Sci USA 97: 12176–12181, 2000), coupled with the availability of a battery of methods for its analysis makes this an ideal model system for studying photobiology among the archaea. Here, we review: (1) the structure of the 2.57 Mbp Halobacterium NRC-1 genome, including a large chromosome, two minichromosomes, and 91 transposable IS elements; (2) the purple membrane regulon, which programs the accumulation of large quantities of the light-driven proton pump, bacteriorhodopsin, and allows for a period of phototrophic growth; (3) components of the sophisticated pathways for color-sensitive phototaxis; (4) the gas vesicle gene cluster, which codes for cell buoyancy organelles; (5) pathways for the production of carotenoid pigments and retinal, (6) processes for the repair of DNA damage; and (7) putative homologs of circadian rhythm regulators. We conclude with a discussion of the power of systems biology for comprehensive understanding of Halobacterium NRC-1 photobiology.

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