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Genomic, pathogenic, and antigenic comparisons of Getah virus strains isolated in 1978 and 2014 in Japan

Authors
  • Nemoto, Manabu1
  • Bannai, Hiroshi1
  • Tsujimura, Koji1
  • Yamanaka, Takashi1
  • Kondo, Takashi1
  • 1 Equine Research Institute, Japan Racing Association, 1400-4, Shiba, Shimotsuke, Tochigi, 329-0412, Japan , Shimotsuke (Japan)
Type
Published Article
Journal
Archives of Virology
Publisher
Springer-Verlag
Publication Date
Mar 26, 2016
Volume
161
Issue
6
Pages
1691–1695
Identifiers
DOI: 10.1007/s00705-016-2840-9
Source
Springer Nature
Keywords
License
Yellow

Abstract

A Getah virus strain isolated during an outbreak in racehorses in Japan in 2014 (14-I-605) was compared with the vaccine strain isolated in 1978 (MI-110). A comparison of the genome sequences of these strains revealed seven amino acid substitutions in non-structural protein 3, and one or two substitutions in each of other non-structural proteins. In contrast, the structural proteins were highly conserved (99.8–99.9 % amino acid sequence identity). Horse antisera raised against the MI-110 strain showed similar virus-neutralization titers against both MI-110 and 14-I-605 strains (512 and 256, respectively). Therefore, antigenic mutation was probably not a direct cause of the outbreak that occurred in 2014.

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