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Genomic Dissection Reveals Locus Response to Stress for Mammalian Acetylcholinesterase

Authors
  • Grant, Alastair D.1
  • Shapira, Michael1
  • Soreq, Hermona1
  • 1 Hebrew University of Jerusalem, Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Jerusalem, Israel , Jerusalem
Type
Published Article
Journal
Cellular and Molecular Neurobiology
Publisher
Springer-Verlag
Publication Date
Dec 01, 2001
Volume
21
Issue
6
Pages
783–797
Identifiers
DOI: 10.1023/A:1015112407079
Source
Springer Nature
Keywords
License
Yellow

Abstract

The mammalian acetylcholinesterase (ACHE) locus was investigated using computational predictive methods and experiments of reverse transcription polymerase chain reaction (RT-PCR). Computational analysis identified two genes downstream to ACHE, an inversely oriented arsenite resistance gene homologue (ARS), and a novel previously unidentified gene (PIX), co-oriented with ACHE. Experimental evidence shows coregulation of murine ACHE and ARS following confined swim, indicating coordinated locus response to stress, that is possibly mediated by altered cholinergic neurotransmission.

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