Genomic correction of familial cardiomyopathy in human engineered cardiac tissues
- Authors
- Type
- Published Article
- Journal
- European Heart Journal
- Publisher
- Oxford University Press
- Publication Date
- Jul 22, 2016
- Volume
- 37
- Issue
- 43
- Pages
- 3282–3284
- Identifiers
- DOI: 10.1093/eurheartj/ehw307
- PMID: 27450564
- PMCID: PMC6425468
- Source
- PubMed Central
- Keywords
- License
- Unknown
Abstract
In this study, we used three-dimensional human engineered cardiac tissue technology to directly show that phospholamban (PLN) R14del mutation impairs cardiac contractility and to demonstrate restoration of contractile properties with targeted genetic correction of this inheritable form of dilated cardiomyopathy.
