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Genomic correction of familial cardiomyopathy in human engineered cardiac tissues

Authors
  • Stillitano, Francesca
  • Turnbull, Irene C.
  • Karakikes, Ioannis
  • Nonnenmacher, Mathieu
  • Backeris, Peter
  • Hulot, Jean-Sébastien
  • Kranias, Evangelia G.
  • Hajjar, Roger J.
  • Costa, Kevin D.
Type
Published Article
Journal
European Heart Journal
Publisher
Oxford University Press
Publication Date
Jul 22, 2016
Volume
37
Issue
43
Pages
3282–3284
Identifiers
DOI: 10.1093/eurheartj/ehw307
PMID: 27450564
PMCID: PMC6425468
Source
PubMed Central
Keywords
License
Unknown

Abstract

In this study, we used three-dimensional human engineered cardiac tissue technology to directly show that phospholamban (PLN) R14del mutation impairs cardiac contractility and to demonstrate restoration of contractile properties with targeted genetic correction of this inheritable form of dilated cardiomyopathy.

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