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Genomic characterization of human adenovirus type 4 strains isolated worldwide since 1953 identifies two separable phylogroups evolving at different rates from their most recent common ancestor.

Authors
  • Gonzalez, Gabriel1
  • Bair, Camden R2
  • Lamson, Daryl M3
  • Watanabe, Hidemi4
  • Panto, Laura4
  • Carr, Michael J5
  • Kajon, Adriana E6
  • 1 Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan. Electronic address: [email protected] , (Japan)
  • 2 Infectious Disease Program, Lovelace Respiratory Research Institute, New Mexico, USA. , (Mexico)
  • 3 Wadsworth Center, New York State Department of Health, New York, USA.
  • 4 Graduate School of Information Science and Technology, Hokkaido University, Japan. , (Japan)
  • 5 Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Japan; National Virus Reference Laboratory, School of Medicine, University College Dublin, Ireland. , (Ireland)
  • 6 Infectious Disease Program, Lovelace Respiratory Research Institute, New Mexico, USA. Electronic address: [email protected] , (Mexico)
Type
Published Article
Journal
Virology
Publisher
Elsevier
Publication Date
Dec 01, 2019
Volume
538
Pages
11–23
Identifiers
DOI: 10.1016/j.virol.2019.08.028
PMID: 31550608
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Species Human mastadenovirus E (HAdV-E) comprises several simian types and a single human type: HAdV-E4, a respiratory and ocular pathogen. RFLP analysis for the characterization of intratypic genetic variability has previously distinguished two HAdV-E4 clusters: prototype (p)-like and a-like. Our analysis of whole genome sequences confirmed two distinct lineages, which we refer to as phylogroups (PGs). PGs I and II comprise the p- and a-like genomes, respectively, and differ significantly in their G + C content (57.7% ± 0.013 vs 56.3% ± 0.015). Sequence differences distinguishing the two clades map to several regions of the genome including E3 and ITR. Bayesian analyses showed that the two phylogroups diverged approximately 602 years before the present. A relatively faster evolutionary rate was identified for PG II. Our data provide a rationale for the incorporation of phylogroup identity to HAdV-E4 strain designation to reflect the identified unique genetic characteristics that distinguish PGs I and II. Copyright © 2019 Elsevier Inc. All rights reserved.

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