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[Genomic approaches to bone and joint diseases. An important role of cross-talk between BMP and Wnt on bone formation].

Authors
  • Katagiri, Takenobu
  • Fukuda, Toru
  • Nojima, Junya
  • Kanomata, Kazuhiro
  • Nakamura, Atsushi
Type
Published Article
Journal
Clinical calcium
Publication Date
Feb 01, 2008
Volume
18
Issue
2
Pages
194–201
Identifiers
DOI: CliCa0802194201
PMID: 18245889
Source
Medline
License
Unknown

Abstract

BMPs bound to specific receptors expressed on cell membrane of target cells, then activate Smad-dependent intracellular signaling. Wnt signaling through LRP5 receptor has been genetically shown to be involved in bone formation in humans. Recently, it was shown that Smad1 degradation requires phosphorylation by GSK3beta, which is suppressed by Wnt signaling. These findings suggest that a cross-talk between BMP and Wnt through Smad1 plays an important role on bone formation.

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