[Genomic approaches to bone and joint diseases. An important role of cross-talk between BMP and Wnt on bone formation].
- Published Article
- Publication Date
Feb 01, 2008
BMPs bound to specific receptors expressed on cell membrane of target cells, then activate Smad-dependent intracellular signaling. Wnt signaling through LRP5 receptor has been genetically shown to be involved in bone formation in humans. Recently, it was shown that Smad1 degradation requires phosphorylation by GSK3beta, which is suppressed by Wnt signaling. These findings suggest that a cross-talk between BMP and Wnt through Smad1 plays an important role on bone formation.
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This record was last updated on 07/03/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/18245889