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Genomic and antigenic relationships between two ‘HoBi’-like strains and other members of the Pestivirus genus

Authors
  • Mósena, Ana Cristina S.1
  • Cibulski, Samuel P.1
  • Weber, Matheus N.1
  • Silveira, Simone1
  • Silva, Mariana S.1
  • Mayer, Fabiana Q.2
  • Roehe, Paulo M.3
  • Canal, Cláudio W.1
  • 1 Universidade Federal do Rio Grande do Sul (UFRGS), Laboratório de Virologia, Faculdade de Veterinária, Av. Bento Gonçalves 9090, Porto Alegre, RS, CEP 91540-000, Brazil , Porto Alegre (Brazil)
  • 2 Instituto de Pesquisas Veterinárias Desidério Finamor, Fundação Estadual de Pesquisa Agropecuária, Laboratório de Biologia Molecular, Eldorado do Sul, RS, Brazil , Eldorado do Sul (Brazil)
  • 3 Universidade Federal do Rio Grande do Sul, Departamento de Microbiologia, Imunologia e Parasitologia-Laboratório de Virologia, Porto Alegre, Rio Grande do Sul, Brazil , Porto Alegre (Brazil)
Type
Published Article
Journal
Archives of Virology
Publisher
Springer-Verlag
Publication Date
Jul 01, 2017
Volume
162
Issue
10
Pages
3025–3034
Identifiers
DOI: 10.1007/s00705-017-3465-3
Source
Springer Nature
License
Yellow

Abstract

‘HoBi’-like viruses comprise a putative new species within the genus Pestivirus of the family Flaviviridae. ‘HoBi’-like viruses have been detected worldwide in batches of fetal calf serum, in surveillance programs for bovine pestiviruses and from animals presenting clinical signs resembling bovine viral diarrhea virus (BVDV)-associated diseases. To date, few complete genome sequences of ‘HoBi’-like viruses are available in public databases. Moreover, detailed analyses of such genomes are still scarce. In an attempt to expand data on the genetic diversity and biology of pestiviruses, two genomes of ‘HoBi’-like viruses recovered from Brazilian cattle were described and characterized in this study. Analysis of the whole genome and antigenic properties of these two new ‘HoBi’-like isolates suggest that these viruses are genetically close to recognized pestiviruses. The present data provide evidence that ‘HoBi’-like viruses are members of the genus Pestivirus and should be formally recognized as a novel species.

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