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Genomic actions of estrogen receptor alpha: what are the targets and how are they regulated?

Authors
Type
Published Article
Journal
Endocrine Related Cancer
1479-6821
Publisher
Bioscientifica
Publication Date
Volume
16
Issue
4
Pages
1073–1089
Identifiers
DOI: 10.1677/ERC-09-0086
PMID: 19628648
Source
Medline
License
Unknown

Abstract

The estrogen receptor alpha (ERalpha) is a ligand-dependent transcription factor that regulates a large number of genes in many different target tissues and is important in the development and progression of breast cancer. ERalpha-mediated transcription is a complex process regulated at many different levels. The interplay between ligand, receptor, DNA sequence, cofactors, chromatin context, and post-translational modifications culminates in transcriptional regulation by ERalpha. Recent technological advances have allowed the identification of ERalpha target genes on a genome-wide scale. In this review, we provide an overview of the progress made in our understanding of the different levels of regulation mediated by ERalpha. We discuss the recent advances in the identification of the ERalpha-binding sites and target gene network and their clinical applications.

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