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Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning

Authors
  • McCullough, Kenneth M.1
  • Chatzinakos, Chris1
  • Hartmann, Jakob1
  • Missig, Galen1
  • Neve, Rachael L.2
  • Fenster, Robert J.1
  • Carlezon, William A. Jr.1
  • Daskalakis, Nikolaos P.1
  • Ressler, Kerry J.1
  • 1 McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA, 02478, USA , Belmont (United States)
  • 2 Gene Transfer Core, Massachusetts General Hospital, Boston, MA, 02114, USA , Boston (United States)
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
Oct 14, 2020
Volume
11
Issue
1
Identifiers
DOI: 10.1038/s41467-020-18985-6
Source
Springer Nature
License
Green

Abstract

Fear and fear extinction learning are dynamic. These dynamic changes are underlined by transcriptional changes. Here, the authors translationally profiled Crh neurons in the amygdala and and identified relevant gene networks.

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