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Genome-wide interaction study of dust mite allergen on lung function in children with asthma.

Authors
  • Forno, Erick1
  • Sordillo, Joanne2
  • Brehm, John1
  • Chen, Wei1
  • Benos, Takis3
  • Yan, Qi1
  • Avila, Lydiana4
  • Soto-Quirós, Manuel4
  • Cloutier, Michelle M5
  • Colón-Semidey, Angel6
  • Alvarez, Maria6
  • Acosta-Pérez, Edna7
  • Weiss, Scott T2
  • Litonjua, Augusto A2
  • Canino, Glorisa7
  • Celedón, Juan C8
  • 1 Division of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; University of Pittsburgh School of Medicine, Pittsburgh, PA.
  • 2 Channing Division of Network Medicine, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA.
  • 3 University of Pittsburgh School of Medicine, Pittsburgh, PA.
  • 4 Department of Pediatric Pulmonology, Hospital Nacional de Niños, San José, Costa Rica.
  • 5 Department of Pediatrics, University of Connecticut Health Center, Farmington, CT.
  • 6 Department of Pediatrics, San Juan, PR.
  • 7 Behavioral Sciences Research Institute, University of Puerto Rico, San Juan, PR.
  • 8 Division of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; University of Pittsburgh School of Medicine, Pittsburgh, PA. Electronic address: [email protected]
Type
Published Article
Journal
The Journal of allergy and clinical immunology
Publication Date
Feb 03, 2017
Identifiers
DOI: 10.1016/j.jaci.2016.12.967
PMID: 28167095
Source
Medline
Keywords
License
Unknown

Abstract

The effect of certain genetic polymorphisms on lung function in children with asthma varies depending on their dust mite allergen exposure level. Future studies should assess whether personalized interventions for these children have a greater impact on lung function.

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