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Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis

Authors
  • Ferrarini, Mariana G.1
  • Lal, Avantika2
  • Rebollo, Rita1
  • Gruber, Andreas J.3
  • Guarracino, Andrea4
  • Gonzalez, Itziar Martinez5
  • Floyd, Taylor6
  • de Oliveira, Daniel Siqueira7
  • Shanklin, Justin8
  • Beausoleil, Ethan8
  • Pusa, Taneli9
  • Pickett, Brett E.8
  • Aguiar-Pulido, Vanessa10
  • 1 University of Lyon, INSA-Lyon, INRA BF2l, Villeurbanne, France , Villeurbanne (France)
  • 2 NVIDIA Corporation, Santa Clara, CA, USA , Santa Clara (United States)
  • 3 University of Konstanz, Konstanz, Germany , Konstanz (Germany)
  • 4 University Of Rome Tor Vergata, Rome, Italy , Rome (Italy)
  • 5 Amsterdam UMC, Amsterdam, The Netherlands , Amsterdam (Netherlands)
  • 6 Cornell University, New York, NY, USA , New York (United States)
  • 7 Laboratoire de Biométrie et Biologie Evolutive, Université de Lyon, Université Lyon 1, CNRS UMR 5558, Villeurbanne, France , Villeurbanne (France)
  • 8 Brigham Young University, Provo, UT, USA , Provo (United States)
  • 9 Luxembourg Centre for Systems Biomedicine, Belvaux, Luxembourg , Belvaux (Luxembourg)
  • 10 University of Miami, Coral Gables, FL, USA , Coral Gables (United States)
Type
Published Article
Journal
Communications Biology
Publisher
Nature Publishing Group UK
Publication Date
May 17, 2021
Volume
4
Issue
1
Identifiers
DOI: 10.1038/s42003-021-02095-0
Source
Springer Nature
License
Green

Abstract

Ferrarini & Lal et al. developed a novel bioinformatic pipeline to explore how SARS-CoV-2 interacts with human respiratory cells using public available host gene expression and viral genome sequence data. Several human genes and proteins were predicted to play a role in the viral life cycle and the host response to SARS-CoV-2 infection.

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