Affordable Access

deepdyve-link
Publisher Website

Genome Writing: Current Progress and Related Applications.

Authors
  • Wang, Yueqiang1
  • Shen, Yue2
  • Gu, Ying2
  • Zhu, Shida3
  • Yin, Ye4
  • 1 BGI-Shenzhen, Shenzhen 518083, China; China National GeneBank, BGI-Shenzhen, Shenzhen 518083, China; Shenzhen Engineering Laboratory for Innovative Molecular Diagnostics, BGI-Shenzhen, Shenzhen 518083, China; Guangdong Provincial Key Laboratory of Genome Read and Write, Shenzhen 518120, China. , (China)
  • 2 BGI-Shenzhen, Shenzhen 518083, China; China National GeneBank, BGI-Shenzhen, Shenzhen 518083, China; BGI-Qingdao, Qingdao 266555, China; Shenzhen Engineering Laboratory for Innovative Molecular Diagnostics, BGI-Shenzhen, Shenzhen 518083, China; Guangdong Provincial Key Laboratory of Genome Read and Write, Shenzhen 518120, China. , (China)
  • 3 BGI-Shenzhen, Shenzhen 518083, China; Shenzhen Engineering Laboratory for Innovative Molecular Diagnostics, BGI-Shenzhen, Shenzhen 518083, China. , (China)
  • 4 BGI Genomics, BGI-Shenzhen, Shenzhen 518083, China; School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116023, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen 2100, Denmark. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Genomics, proteomics & bioinformatics
Publication Date
Feb 01, 2018
Volume
16
Issue
1
Pages
10–16
Identifiers
DOI: 10.1016/j.gpb.2018.02.001
PMID: 29474887
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The ultimate goal of synthetic biology is to build customized cells or organisms to meet specific industrial or medical needs. The most important part of the customized cell is a synthetic genome. Advanced genomic writing technologies are required to build such an artificial genome. Recently, the partially-completed synthetic yeast genome project represents a milestone in this field. In this mini review, we briefly introduce the techniques for de novo genome synthesis and genome editing. Furthermore, we summarize recent research progresses and highlight several applications in the synthetic genome field. Finally, we discuss current challenges and future prospects. Copyright © 2018. Production and hosting by Elsevier B.V.

Report this publication

Statistics

Seen <100 times