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Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses.

Authors
  • Orr, N1
  • Back, W
  • Gu, J
  • Leegwater, P
  • Govindarajan, P
  • Conroy, J
  • Ducro, B
  • Van Arendonk, J A M
  • MacHugh, D E
  • Ennis, S
  • Hill, E W
  • Brama, P A J
  • 1 Section of Veterinary Clinical Studies, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin, Ireland. , (Ireland)
Type
Published Article
Journal
Animal genetics
Publication Date
Dec 01, 2010
Volume
41 Suppl 2
Pages
2–7
Identifiers
DOI: 10.1111/j.1365-2052.2010.02091.x
PMID: 21070269
Source
Medline
License
Unknown

Abstract

The recent completion of the horse genome and commercial availability of an equine SNP genotyping array has facilitated the mapping of disease genes. We report putative localization of the gene responsible for dwarfism, a trait in Friesian horses that is thought to have a recessive mode of inheritance, to a 2-MB region of chromosome 14 using just 10 affected animals and 10 controls. We successfully genotyped 34,429 SNPs that were tested for association with dwarfism using chi-square tests. The most significant SNP in our study, BIEC2-239376 (P(2df)=4.54 × 10(-5), P(rec)=7.74 × 10(-6)), is located close to a gene implicated in human dwarfism. Fine-mapping and resequencing analyses did not aid in further localization of the causative variant, and replication of our findings in independent sample sets will be necessary to confirm these results.

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