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Genome-wide linkage in a highly consanguineous pedigree reveals two novel loci on chromosome 7 for non-syndromic familial Premature Ovarian Failure.

Authors
  • Sandrine Caburet
  • Petra Zavadakova
  • Ziva Ben-Neriah
  • Kamal Bouhali
  • Aurélie Dipietromaria
  • Céline Charon
  • Céline Besse
  • Paul Laissue
  • Vered Chalifa-Caspi
  • Sophie Christin-Maitre
  • Daniel Vaiman
  • Giovanni Levi
  • Reiner A Veitia
  • Marc Fellous
Identifiers
DOI: 10.1371/journal.pone.0033412
Source
CdV-UPMC
License
Unknown

Abstract

The human condition known as Premature Ovarian Failure (POF) is characterized by loss of ovarian function before the age of 40. A majority of POF cases are sporadic, but 10-15% are familial, suggesting a genetic origin of the disease. Although several causal mutations have been identified, the etiology of POF is still unknown for about 90% of the patients. We report a genome-wide linkage and homozygosity analysis in one large consanguineous Middle-Eastern POF-affected family presenting an autosomal recessive pattern of inheritance. We identified two regions with a LOD(max) of 3.26 on chromosome 7p21.1-15.3 and 7q21.3-22.2, which are supported as candidate regions by homozygosity mapping. Sequencing of the coding exons and known regulatory sequences of three candidate genes (DLX5, DLX6 and DSS1) included within the largest region did not reveal any causal mutations. We detect two novel POF-associated loci on human chromosome 7, opening the way to the identification of new genes involved in the control of ovarian development and function.

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