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Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3.

Authors
  • 1
  • 1 MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Type
Published Article
Journal
Obesity
1930-739X
Publisher
Wiley Blackwell (Blackwell Publishing)
Publication Date
Volume
22
Issue
10
Pages
2252–2259
Identifiers
DOI: 10.1002/oby.20840
PMID: 25044758
Source
Medline
License
Unknown

Abstract

Analysis of BMI[x] showed differences to that of conventional BMI. The association signal at ADCY3 appeared to be driven by a missense variant and it was strongly correlated with expression of this gene. Our work highlights the importance of well understood phenotype use (and the danger of convention) in characterising genetic contributions to complex traits.

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