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Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium.

Authors
  • Debette, Stéphanie
  • Bis, Joshua C
  • Fornage, Myriam
  • Schmidt, Helena
  • Ikram, M Arfan
  • Sigurdsson, Sigurdur
  • Heiss, Gerardo
  • Struchalin, Maksim
  • Smith, Albert V
  • van der Lugt, Aad
  • DeCarli, Charles
  • Lumley, Thomas
  • Knopman, David S
  • Enzinger, Christian
  • Eiriksdottir, Gudny
  • Koudstaal, Peter J
  • DeStefano, Anita L
  • Psaty, Bruce M
  • Dufouil, Carole
  • Catellier, Diane J
  • And 33 more
Type
Published Article
Journal
Stroke
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Feb 01, 2010
Volume
41
Issue
2
Pages
210–217
Identifiers
DOI: 10.1161/STROKEAHA.109.569194
PMID: 20044523
Source
Medline
Keywords
License
Unknown

Abstract

This first community-based, genome-wide association study on covert MRI infarcts uncovered novel associations. Although replication of the association with top single nucleotide polymorphisms failed, possibly because of insufficient power, results in the black population sample are encouraging, and further efforts at replication are needed.

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