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Genome organization: Tag it, move it, place it.

Authors
  • Peng, Audrey Yi Tyan1
  • Kolhe, Janhavi A1
  • Behrens, Lindsey D1
  • Freeman, Brian C2
  • 1 University of Illinois, Urbana-Champaign, Department of Cell and Developmental Biology, Urbana, IL, 61801, USA.
  • 2 University of Illinois, Urbana-Champaign, Department of Cell and Developmental Biology, Urbana, IL, 61801, USA. Electronic address: [email protected]
Type
Published Article
Journal
Current opinion in cell biology
Publication Date
Nov 06, 2020
Volume
68
Pages
90–97
Identifiers
DOI: 10.1016/j.ceb.2020.10.005
PMID: 33166737
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Chromosomes are selectively organized within the nuclei of interphase cells reflecting the current fate of each cell and are reorganized in response to various physiological cues to maintain homeostasis. Although substantial progress is being made to establish the various patterns of genome architecture, less is understood on how chromosome folding/positioning is achieved. Here, we discuss recent insights into the cellular mechanisms dictating chromatin movements including the use of epigenetic modifications and allosterically regulated transcription factors, as well as a nucleoskeleton system comprised of actin, myosin, and actin-binding proteins. Together, these nuclear factors help coordinate the positioning of both general and cell-specific genomic architectural features. Published by Elsevier Ltd.

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