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Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype

Authors
  • Manakhov, Andrey D.1, 2, 3
  • Mintseva, Maria Yu.1, 2
  • Andreev, Igor A.2
  • Uralsky, Lev I.1
  • Andreeva, Tatiana V.1, 2
  • Trapezov, Oleg V.4, 5
  • Rogaev, Evgeny I.1, 2, 3, 6
  • 1 Russian Academy of Sciences, Moscow, 119333, Russia , Moscow (Russia)
  • 2 Lomonosov Moscow State University, Moscow, 119192, Russia , Moscow (Russia)
  • 3 Sirius University of Science and Technology, Sochi, 354340, Russia , Sochi (Russia)
  • 4 Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia , Novosibirsk (Russia)
  • 5 Novosibirsk State University, Novosibirsk, 630090, Russia , Novosibirsk (Russia)
  • 6 University of Massachusetts Medical School, Worcester, MA, 01604, USA , Worcester (United States)
Type
Published Article
Journal
Scientific Reports
Publisher
Springer Nature
Publication Date
Sep 28, 2020
Volume
10
Issue
1
Identifiers
DOI: 10.1038/s41598-020-72239-5
Source
Springer Nature
License
Green

Abstract

Over 35 fur colours have been described in American mink (Neovison vison), only six of which have been previously linked to specific genes. Moyle fur colour belongs to a wide group of brownish colours that are highly similar to each other, which complicates selection and breeding procedures. We performed whole genome sequencing for two American minks with Moyle (m/m) and Violet (a/a m/m /p/p) phenotypes. We identified two frame-shift mutations in the gene encoding Ras-related protein-38 (RAB38), which regulates the trafficking of tyrosinase-containing vesicles to maturing melanosomes. The results highlight the role of RAB38 in the biogenesis of melanosomes and melanin and the genetic mechanism contributing to hair colour variety and intensity. These data are also useful for tracking economically valuable fur traits in mink breeding programmes.

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