Affordable Access

Access to the full text

Genetics of rheumatoid arthritis: confronting complexity

Authors
  • Gregersen, Peter K1
  • 1 North Shore University Hospital, Manhasset, New York, USA , Manhasset
Type
Published Article
Journal
Arthritis Research & Therapy
Publisher
Springer Science and Business Media LLC
Publication Date
Oct 26, 1999
Volume
1
Issue
1
Identifiers
DOI: 10.1186/ar9
Source
Springer Nature
Keywords
License
Yellow

Abstract

The genetic basis for rheumatoid arthritis (RA) is likely to be extremely complex. Even the role of MHC genes remains to be fully defined, and may involve interactive genetic effects. The difficulty of precisely defining the clinical phenotype, as well as underlying genetic heterogeneity, complicates the problem. In addition, stochastic genetic or physiologic events may contribute to the low penetrance of susceptibility genes. This situation parallels developing paradigms for other autoimmune disorders, in which many different genes each appear to contribute a small amount to overall risk for disease, and where severity and specific phenotypic subtypes are subject to genetic effects. The completion of the human genome project, along with advances in informatics, will be required to reach a deeper understanding of RA. It is likely that this will involve an iterative and interactive process between several different scientific disciplines.

Report this publication

Statistics

Seen <100 times