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Genetics of migraine and pharmacogenomics: some considerations.

Authors
  • Piane, Maria
  • Lulli, Patrizia
  • Farinelli, Ivano
  • Simeoni, Simona
  • De Filippis, Sergio
  • Patacchioli, Francesca Romana
  • Martelletti, Paolo
Type
Published Article
Journal
The journal of headache and pain
Publication Date
Dec 01, 2007
Volume
8
Issue
6
Pages
334–339
Identifiers
PMID: 18058067
Source
Medline
License
Unknown

Abstract

Migraine is a complex disorder caused by a combination of genetic and environmental factors. Although family and twin studies show that there is a genetic component in migraine, no genes predisposing to common forms of the disorder, migraine with and without aura, have been identified. Patients with migraine respond differently to a given drug administered. The efficacy of therapy and the occurrence of adverse drug response are a consequence of individual variability. Genetic profiling of predisposition to migraine should facilitate the development of more effective diagnostic and therapeutic applications. The development of International Hap Map project could provide a powerful tool for identification of the candidate genes in this complex disease and pharmacogenomics research could be the promise for individualized treatments and prevention of adverse drug response.

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