Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Genetics and epigenetics of gliomas.

Authors
  • Suvà, Mario Luca
Type
Published Article
Journal
Swiss Medical Weekly
Publisher
"EMH Swiss Medical Publishers, Ltd."
Publication Date
Jan 01, 2014
Volume
144
Identifiers
DOI: 10.4414/smw.2014.14018
PMID: 25356909
Source
Medline
License
Unknown

Abstract

Gliomas are the most common primary intrinsic brain tumours. Their classification is based on phenotypic resemblance to normal glial cells (astrocytomas, oligodendrogliomas, mixed oligoastrocytomas) and pathological grading. Whereas this system is clinically relevant and has been the basis for our understanding of gliomas, systematic use of next-generation sequencing has transformed our knowledge of their pathogenesis and has uncovered genetic changes in an unanticipated number of genes and regulatory elements. In the past few years, in-depth analysis of low-grade astrocytomas and glioblastomas in both paediatric and adult populations has clarified our molecular understanding of these diseases, with distinct molecular events occurring in different age groups. In oligodendrogliomas, recent studies have highlighted mutations in candidate tumour suppressor genes located on 1p/19q, chromosome arms frequently deleted in this tumour. In this review, we discuss recent discoveries in the genetics of adult and paediatric gliomas, and highlight how some of the founding genetic mutations reshape the cancer epigenome. These studies provide an in-depth view of the molecular routes leading to brain tumour development and will be key for refining classification systems and improving clinical care.

Report this publication

Statistics

Seen <100 times