Affordable Access

deepdyve-link
Publisher Website

Genetically-programmed, mesenchymal stromal cell-laden & mechanically strong 3D bioprinted scaffolds for bone repair

Authors
  • Abu Awwad, Hosam Al-Deen M.1
  • Thiagarajan, Lalitha1
  • Kanczler, Janos M.2
  • Amer, Mahetab H.1
  • Bruce, Gordon1
  • Lanham, Stuart2
  • Rumney, Robin M.H.3
  • Oreffo, Richard O.C.2
  • Dixon, James E.1
  • 1 Regenerative Medicine & Cellular Therapies Division, The University of Nottingham Biodiscovery Institute (BDI), School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK
  • 2 Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK
  • 3 School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth PO1 2DT, UK
Type
Published Article
Journal
Journal of controlled release : official journal of the Controlled Release Society
Publication Date
Sep 10, 2020
Volume
325
Pages
335–346
Identifiers
DOI: 10.1016/j.jconrel.2020.06.035
PMID: 32629135
PMCID: PMC7445425
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

• Efficient osteogenic programming of hMSCs by cell-transducing GET-RUNX2. • Osteogenesis by controlled release of GET-RUNX2 from PLGA MPs. • Mechanically strong biodegradable PLGA/PEG scaffolds containing MPs & hMSCs. • 3D bioprinting of cell- and MP-laden scaffolds for personalized implants.

Report this publication

Statistics

Seen <100 times