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Genetically modified mouse models for pharmacogenomic research.

Authors
  • Liggett, Stephen B
Type
Published Article
Journal
Nature reviews. Genetics
Publication Date
Sep 01, 2004
Volume
5
Issue
9
Pages
657–663
Identifiers
PMID: 15372087
Source
Medline
License
Unknown

Abstract

It is now evident that differences in the DNA sequence of genes involved with drug action can lead to interindividual differences in effectiveness and adverse reactions to therapeutic drugs. Pharmacogenomics raises the possibility that drug discovery and patient management could move from a 'one drug fits all' approach to one in which therapy is tailored to patients' genomes. Genetically modified mice that mimic human variation in drug response can provide one of the tools to move the field towards these goals.

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