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Genetically abnormal circulating cells in lung cancer patients: an antigen-independent fluorescence in situ hybridization-based case-control study.

Authors
  • Katz, Ruth L
  • He, Weigong
  • Khanna, Abha
  • Fernandez, Ricardo L
  • Zaidi, Tanweer M
  • Krebs, Matthew
  • Caraway, Nancy P
  • Zhang, Hua-Zhong
  • Jiang, Feng
  • Spitz, Margaret R
  • Blowers, David P
  • Jimenez, Carlos A
  • Mehran, Reza J
  • Swisher, Stephen G
  • Roth, Jack A
  • Morris, Jeffrey S
  • Etzel, Carol J
  • El-Zein, Randa
Type
Published Article
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Date
Aug 01, 2010
Volume
16
Issue
15
Pages
3976–3987
Identifiers
DOI: 10.1158/1078-0432.CCR-09-3358
PMID: 20651054
Source
Medline
License
Unknown

Abstract

We have developed a sensitive and quantitative antigen-independent FISH-based test for detecting CACs in peripheral blood of patients with NSCLC, which showed a significant correlation with the presence of cancer. If this pilot study can be validated in a larger study, CACs may have a role in the management of patients with NSCLC.

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