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Short Communication: Genetic Variation in Human IL10 Proximal Promoter and Susceptibility to HIV-1 Infection in Mali, West Africa.

Authors
  • Dabitao, Djeneba1, 2
  • Dembele, Mamadou1
  • Urbanowski, Michael3
  • Kone, Bourahima1
  • Wague, Mamadou1
  • Coulibaly, Nadie1
  • Sarro, Yeya Dit Sadio1
  • Baya, Bocar1
  • Goita, Drissa1
  • Dao, Sounkalo1
  • Belson, Michael4
  • Klein, Sabra L5
  • Achenbach, Chad6, 7
  • Holl, Jane L6, 7
  • Diakite, Mahamadou1
  • Doumbia, Seydou1
  • Bream, Jay H5, 8
  • Bishai, William R3
  • Diallo, Souleymane1
  • Murphy, Robert L6, 7
  • 1 Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University Clinical Research Center (UCRC), University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa. , (Mali)
  • 2 School for Professional Studies, Northwestern University (NU), Chicago, Illinois, USA.
  • 3 Department of Infectious Diseases, Center for Tuberculosis Research, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • 4 Collaborative Clinical Research Branch (CCRB), Division of Clinical Research (DCR), National Institutes of Allergy and Infectious Diseases (NIAID), Bethesda, Maryland, USA.
  • 5 Johns Hopkins Bloomberg School of Public Health, W. Harry Feinstone Department of Molecular Microbiology and Immunology, Baltimore, Maryland, USA.
  • 6 Division of Infectious Diseases and Institute for Global Health, Feinberg School of Medicine, Northwestern University (NU), Chicago, Illinois, USA.
  • 7 Biological Sciences Division, University of Chicago, Chicago, Illinois, USA.
  • 8 Graduate Program in Immunology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Type
Published Article
Journal
AIDS Research and Human Retroviruses
Publisher
Mary Ann Liebert
Publication Date
Jan 01, 2021
Volume
37
Issue
1
Pages
57–61
Identifiers
DOI: 10.1089/AID.2020.0140
PMID: 33045845
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

It is now recognized that to fully understand the role of host genetic variation on susceptibility to HIV-1 infection, investigations must be extended to African populations. We sought to determine if genetic variation in IL10 are associated with HIV-1 infection in a West African cohort in Mali. HIV-infected and -uninfected individuals were genotyped for three common single nucleotide polymorphisms (SNPs) located at positions -592 (C/A), -819 (C/T), and -1082 (G/A) of the IL10 promoter. We found that the ATA haplotype, which has been previously associated with low IL-10 expression, was the most represented in the cohort. Although we observed a trend toward an increased frequency of ATA/ATA carriage in HIV-infected compared with -uninfected individuals, the difference was not statistically significant. Similarly, individual IL10 SNPs were not significantly enriched in the HIV-infected group, suggesting that IL10 genetic variants are not associated with HIV-1 in this West African cohort from Mali.

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