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Genetic variants associated with skin aging in the Chinese Han population.

Authors
  • Gao, Wenshan1
  • Tan, Jingze2
  • Hüls, Anke3
  • Ding, Anan4
  • Liu, Yu4
  • Matsui, Mary S5
  • Vierkötter, Andrea3
  • Krutmann, Jean3
  • Schikowski, Tamara6
  • Jin, Li7
  • Wang, Sijia8
  • 1 Chinese Academy of Sciences Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China; University of Chinese Academy of Sciences, Beijing 100049, China. , (China)
  • 2 State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China. , (China)
  • 3 IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. , (Germany)
  • 4 Chinese Academy of Sciences Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China. , (China)
  • 5 The Estee Lauder Companies Inc, Melville, NY, United States, United States. , (United States)
  • 6 IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. Electronic address: [email protected] , (Germany)
  • 7 Chinese Academy of Sciences Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China; State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China; Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu 225300, China. Electronic address: [email protected] , (China)
  • 8 Chinese Academy of Sciences Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China; State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Journal of dermatological science
Publication Date
Apr 01, 2017
Volume
86
Issue
1
Pages
21–29
Identifiers
DOI: 10.1016/j.jdermsci.2016.12.017
PMID: 28057405
Source
Medline
Keywords
License
Unknown

Abstract

Our results identified genetic risk factors for signs of skin aging (pigmentation, wrinkles or laxity) in Han Chinese. We also found that the manifestation of skin aging is further modified by anatomical site. Together with previous work, our results also suggest that different genetic variants could be responsible for distinct skin aging signs characteristic of Caucasians compared to East Asians.

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