Affordable Access

deepdyve-link
Publisher Website

A Genetic Variant of the Serine Racemase Gene Is Associated with Schizophrenia

Authors
  • Morita, Yukitaka
  • Ujike, Hiroshi
  • Tanaka, Yuji
  • Otani, Kyohei
  • Kishimoto, Makiko
  • Morio, Akiko
  • Kotaka, Tatsuya
  • Okahisa, Yuko
  • Matsushita, Masayuki
  • Morikawa, Akiko
  • Hamase, Kenji
  • Zaitsu, Kiyoshi
  • Kuroda, Shigetoshi
Type
Published Article
Journal
Biological Psychiatry
Publisher
Elsevier
Publication Date
Jan 01, 2007
Accepted Date
Jul 19, 2006
Volume
61
Issue
10
Pages
1200–1203
Identifiers
DOI: 10.1016/j.biopsych.2006.07.025
Source
Elsevier
Keywords
License
Unknown

Abstract

Background Serine racemase (SRR) is a brain-enriched enzyme that converts l-serine to d-serine, which acts as an endogenous ligand of N-methyl d-aspartate (NMDA) receptors. Dysfunction of SRR may reduce the function of NMDA receptors and susceptibility to schizophrenia. Methods We genotyped three single-nucleotide polymorphisms (SNPs) of the 5′ region of the SRR gene in 525 patients with schizophrenia and 524 healthy controls. Effects of SNPs on the promoter activity and on serum levels of total and d-serine were examined. Results We found a significant excess of the IVS1a+465C allele of the SRR gene in schizophrenia, especially in the paranoid subtype (p = .0028). A reporter assay showed that the IVS1a+465C allele had 60% lower promoter activity than did the IVS1a+465G allele. Conclusions The IVS1a+465C allele of the SRR gene, which reduces expression of the gene, is a risk factor for schizophrenia, especially the paranoid subtype.

Report this publication

Statistics

Seen <100 times