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Genetic rescue of muscle defects associated with a mutant Drosophila melanogaster tropomyosin allele.

Authors
  • E A Fyrberg
  • C C Karlik
Publication Date
Aug 01, 1987
Source
PMC
Keywords
License
Unknown

Abstract

We describe a genetic transformation system which should prove useful for investigating tropomyosin assembly and function. Muscle abnormalities associated with a defective tropomyosin allele were corrected by integrating the wild-type gene into germ line chromosomes. The transformation protocol permits application of directed mutagenesis techniques in investigations of contractile regulatory mechanisms.

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