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Genetic predisposition to familial neuroblastoma: identification of two novel genomic regions at 2p and 12p.

Authors
  • Longo, Luca
  • Panza, Emanuele
  • Schena, Francesca
  • Seri, Marco
  • Devoto, Marcella
  • Romeo, Giovanni
  • Bini, Carla
  • Pappalardo, Giuseppe
  • Tonini, Gian Paolo
  • Perri, Patrizia
Type
Published Article
Journal
Human heredity
Publication Date
Jan 01, 2007
Volume
63
Issue
3-4
Pages
205–211
Identifiers
PMID: 17317969
Source
Medline
License
Unknown

Abstract

Evidence of linkage was reported at 16p in North American families, whereas our studies excluded this interval and indicated other loci for disease predisposition, thus confirming the remarkable genetic heterogeneity of NB. These results suggest an oligogenic inheritance in NB involving more loci in genetic determination of the disease.

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