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Genetic polymorphisms of DNA repair gene XRCC1 and risk of uterine leiomyoma.

Authors
  • Yang, Yang
  • Zhai, Xian Dun
  • Gao, Lin Bo
  • Li, Shi Liu
  • Wang, Zheng
  • Chen, Guo Di
Type
Published Article
Journal
Molecular and Cellular Biochemistry
Publisher
Springer-Verlag
Publication Date
May 01, 2010
Volume
338
Issue
1-2
Pages
143–147
Identifiers
DOI: 10.1007/s11010-009-0347-3
PMID: 20013148
Source
Medline
License
Unknown

Abstract

The objective was to study the relationship between the polymorphisms of the DNA repair gene XRCC1 Arg399Gln, Arg194Trp, and Arg280His uterine leiomyoma in a Chinese population. In the case-control study, we compared the XRCC1 gene polymorphism of 136 uterine leiomyoma patients and 140 healthy controls by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The results suggested that the genotype Arg/Arg of codon 280 was significantly different from its heterozygote (odds ratio [OR] = 3.633, 95% confidence interval [CI]: 2.147-6.148). In conclusion, the results suggest that polymorphism of XRCC1 Arg280His was associated with the increased risk of uterine leiomyoma in a Chinese population.

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