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Genetic polymorphism of the binding domain of surfactant protein-A2 increases susceptibility to meningococcal disease.

Authors
  • Jack, Dominic L
  • Cole, Joby
  • Naylor, Simone C
  • Borrow, Raymond
  • Kaczmarski, Edward B
  • Klein, Nigel J
  • Read, Robert C
Type
Published Article
Journal
Clinical Infectious Diseases
Publisher
Oxford University Press
Publication Date
Dec 01, 2006
Volume
43
Issue
11
Pages
1426–1433
Identifiers
PMID: 17083016
Source
Medline
License
Unknown

Abstract

Gene polymorphism resulting in the substitution of glutamine with lysine at residue 223 in the carbohydrate recognition domain of SP-A2 increases susceptibility to meningococcal disease, as well as the risk of death.

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