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Genetic and molecular biology of systemic lupus erythematosus among Iranian patients: an overview

Authors
  • Gachpazan, Meisam1
  • Akhlaghipour, Iman1
  • Rahimi, Hamid Reza1
  • Saburi, Ehsan1
  • Mojarrad, Majid1
  • Abbaszadegan, Mohammad Reza1
  • Moghbeli, Meysam1
  • 1 Mashhad University of Medical Sciences, Mashhad, Iran , Mashhad (Iran)
Type
Published Article
Journal
Autoimmunity Highlights
Publisher
BioMed Central
Publication Date
Jan 30, 2021
Volume
12
Issue
1
Identifiers
DOI: 10.1186/s13317-020-00144-y
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundSystemic lupus erythematosus (SLE) is a clinicopathologically heterogeneous chronic autoimmune disorder affecting different organs and tissues. It has been reported that there is an increasing rate of SLE incidence among Iranian population. Moreover, the Iranian SLE patients have more severe clinical manifestations compared with other countries. Therefore, it is required to introduce novel methods for the early detection of SLE in this population. Various environmental and genetic factors are involved in SLE progression.Main bodyIn present review we have summarized all of the reported genes which have been associated with clinicopathological features of SLE among Iranian patients.ConclusionsApart from the reported cytokines and chemokines, it was interestingly observed that the apoptosis related genes and non-coding RNAs were the most reported genetic abnormalities associated with SLE progression among Iranians. This review clarifies the genetics and molecular biology of SLE progression among Iranian cases. Moreover, this review paves the way of introducing an efficient panel of genetic markers for the early detection and better management of SLE in this population.

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