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Genetic modification of liver grafts with an adenoviral vector encoding the Bcl-2 gene improves organ preservation.

Authors
  • Bilbao, G
  • Contreras, J L
  • Gómez-Navarro, J
  • Eckhoff, D E
  • Mikheeva, G
  • Krasnykh, V
  • Hynes, T
  • Thomas, F T
  • Thomas, J M
  • Curiel, D T
Type
Published Article
Journal
Transplantation Journal
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Mar 27, 1999
Volume
67
Issue
6
Pages
775–783
Identifiers
PMID: 10199723
Source
Medline
License
Unknown

Abstract

We have demonstrated a novel approach to reducing the preservation injury to liver grafts with the human Bcl-2 gene. This approach may allow a longer preservation time, potentially reduce the incidence of primary nonfunction, decrease the immunogenicity of the cold injured organ, and increase the safer use of "marginal" liver grafts.

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