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Genetic mapping a meiotic driver that causes sex ratio distortion in the mosquito Aedes aegypti.

Authors
  • Shin, Dongyoung
  • Mori, Akio
  • Severson, David W
Type
Published Article
Journal
The Journal of heredity
Publication Date
Jan 01, 2012
Volume
103
Issue
2
Pages
303–307
Identifiers
DOI: 10.1093/jhered/esr134
PMID: 22308303
Source
Medline
License
Unknown

Abstract

An endogenous meiotic driver in the dengue and yellow fever vector mosquito Aedes aegypti can cause highly male-biased sex ratio distortion in crosses from suitable genetic backgrounds. We previously selected a strain that carries a strong meiotic drive gene (D) linked with the male-determining allele (M) on chromosome 1 in A. aegypti. Here, we performed segregation analysis of the M(D) locus among backcross (BC(1)) progeny from a driver male and drive-sensitive females. Assessment of sex ratios among BC(2) progeny showed ∼5.2% recombination between the M(D) locus and the sex determination locus. Multipoint linkage mapping across this region revealed consistent marker orders and recombination frequencies with the existing reference linkage map and placed the M(D) locus within a 6.5-cm interval defined by the LF159 locus and microsatellite marker 446GAA, which should facilitate future positional cloning efforts.

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