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Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism.

Authors
  • Sl, Smalley
  • V, Kustanovich
  • Sl, Minassian
  • Jl, Stone
  • Mn, Ogdie
  • Jj, Mcgough
  • Jt, Mccracken
  • Il, Macphie
  • C, Francks
  • Se, Fisher
  • Rm, Cantor
  • Ap, Monaco
  • Stanley F. Nelson
Type
Published Article
Journal
The American Journal of Human Genetics
Publisher
Elsevier
Volume
71
Issue
4
Pages
959–963
Source
Nelson Lab
License
Unknown

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed behavioral disorder in childhood and likely represents an extreme of normal behavior. ADHD significantly impacts learning in school-age children and leads to impaired functioning throughout the life span. There is strong evidence for a genetic etiology of the disorder, although putative alleles, principally in dopamine-related pathways suggested by candidate-gene studies, have very small effect sizes. We use affected-sib-pair analysis in 203 families to localize the first major susceptibility locus for ADHD to a 12-cM region on chromosome 16p13 (maximum LOD score 4.2; P=.000005), building upon an earlier genomewide scan of this disorder. The region overlaps that highlighted in three genome scans for autism, a disorder in which inattention and hyperactivity are common, and physically maps to a 7-Mb region on 16p13. These findings suggest that variations in a gene on 16p13 may contribute to common deficits found in both ADHD and autism.

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