Affordable Access

Access to the full text

Genetic heterogeneity among bovine leukemia viruses in Japan and their relationship to leukemogenicity

Authors
  • Inoue, Emi1
  • Matsumura, Keiko1
  • Maekawa, Kohei1
  • Nagatsuka, Kenta1
  • Nobuta, Miwako1
  • Hirata, Moe1
  • Minagawa, Airi1
  • Osawa, Yoshiaki1
  • Okazaki, Katsunori1, 2
  • 1 Health Sciences University of Hokkaido, Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan , Hokkaido (Japan)
  • 2 Health Sciences University of Hokkaido, Division of Medicinal Science, The Research Institute of Personalized Health Sciences, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan , Hokkaido (Japan)
Type
Published Article
Journal
Archives of Virology
Publisher
Springer-Verlag
Publication Date
Mar 09, 2011
Volume
156
Issue
7
Pages
1137–1141
Identifiers
DOI: 10.1007/s00705-011-0955-6
Source
Springer Nature
Keywords
License
Yellow

Abstract

Bovine leukemia virus (BLV) infection in cattle causes persistent lymphocytosis, and a few percent of infected animals develop lymphoid tumors, namely enzootic bovine leukosis (EBL). In this study, a 440-bp fragment of the env gene was amplified from 204 tumor samples collected from different regions of Japan and analyzed by restriction fragment length polymorphism (RFLP) to determine the association of BLV with EBL. Of the seven RFLP types defined, types I, II, and III were dominant and found in 12.7, 75.0, and 8.3% of tumor samples, respectively. Cattle harboring type III virus were significantly older than other animals at the time of diagnosis of EBL. Type III viruses were found in approximately 33% and 5.5% of Japanese Black and Holstein cattle, respectively, with EBL. These findings indicate that genetically distinct BLV was associated with EBL in Japan and that the genetic profile may influence the leukemogenicity of the virus.

Report this publication

Statistics

Seen <100 times