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Genetic and Epigenetic Regulation of Immune Response and Resistance to Infectious Diseases in Domestic Ruminants.

Authors
  • Emam, Mehdi1
  • Livernois, Alexandra2
  • Paibomesai, Marlene3
  • Atalla, Heba2
  • Mallard, Bonnie4
  • 1 Department of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada; Department of Animal Biosciences, Center for Genetic Improvement of Livestock, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada. Electronic address: [email protected] , (Canada)
  • 2 Department of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada. , (Canada)
  • 3 Ontario Ministry of Agriculture and Rural Affairs, 1 Stone Road W, Guelph, Ontario N1G 4Y2, Canada. , (Canada)
  • 4 Department of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada; Department of Animal Biosciences, Center for Genetic Improvement of Livestock, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada. , (Canada)
Type
Published Article
Journal
The Veterinary clinics of North America. Food animal practice
Publication Date
Nov 01, 2019
Volume
35
Issue
3
Pages
405–429
Identifiers
DOI: 10.1016/j.cvfa.2019.07.002
PMID: 31590895
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Infectious diseases are the outcome of complex interactions between the host, pathogen, and environment. After exposure to a pathogen, the host immune system uses various mechanisms to remove the pathogen. However, environmental factors and characteristics of pathogens can compromise the host immune responses and subsequently alter the outcome of infection. In this article, genetic and epigenetic factors that shape the individual variation in mounting protective responses are reviewed. Different approaches that have been used by researchers to investigate the genetic regulation of immunity in ruminants and various sources of genetic information are discussed. Copyright © 2019 Elsevier Inc. All rights reserved.

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