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Genetic engineering in nonhuman primates for human disease modeling

Authors
  • Sato, Kenya1
  • Sasaki, Erika1, 2
  • 1 Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki-shi, 210-0821, Japan , Kawasaki-ku (Japan)
  • 2 Advanced Research Center, Keio University, Shinjuku-ku, Tokyo, 160-8582, Japan , Tokyo (Japan)
Type
Published Article
Journal
Journal of Human Genetics
Publisher
Springer Nature
Publication Date
Dec 04, 2017
Volume
63
Issue
2
Pages
125–131
Identifiers
DOI: 10.1038/s10038-017-0351-5
Source
Springer Nature
License
Green

Abstract

Nonhuman primate (NHP) experimental models have contributed greatly to human health research by assessing the safety and efficacy of newly developed drugs, due to their physiological and anatomical similarities to humans. To generate NHP disease models, drug-inducible methods, and surgical treatment methods have been employed. Recent developments in genetic and developmental engineering in NHPs offer new options for producing genetically modified disease models. Moreover, in recent years, genome-editing technology has emerged to further promote this trend and the generation of disease model NHPs has entered a new era. In this review, we summarize the generation of conventional disease model NHPs and discuss new solutions to the problem of mosaicism in genome-editing technology.

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