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Genetic Diversity, Complicated Recombination, and Deteriorating Drug Resistance Among HIV-1-Infected Individuals in Wuhan, China.

Authors
  • Zhang, Yan1, 2
  • Luo, Yanhe3
  • Li, Yang1, 2
  • Zhang, Yawu3
  • Wu, Wenying1
  • Peng, Hong3
  • Han, Lijun3
  • Chen, Yaokai4
  • Ruan, Lianguo3
  • Yang, Rongge1
  • 1 Research Group of HIV-1 Molecular Epidemiology and Virology, The State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China. , (China)
  • 2 University of Chinese Academy of Sciences, Beijing, China. , (China)
  • 3 Department of Infectious Disease, Wuhan Jinyintan Hospital, Wuhan, China. , (China)
  • 4 Division of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing, China. , (China)
Type
Published Article
Journal
AIDS Research and Human Retroviruses
Publisher
Mary Ann Liebert
Publication Date
Sep 28, 2020
Identifiers
DOI: 10.1089/AID.2020.0142
PMID: 32878449
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To identify genotype distribution and drug resistance in people infected by HIV-1 in Wuhan, China, 105 infected people diagnosed with HIV-1 from January to December in 2019 were involved in this study. Ninety-eight gag genes, 101 PR genes, and 98 RT genes were successfully amplified. The phylogenetic analysis results showed that CRF01_AE (38.2%) and CRF07_BC (35.3%) were the two dominant genotypes, followed by CRF55_01B (6.9%), CRF59_01B (2.0%), B (2.0%), B' (2.0%), CRF08_BC (1.0%), CRF80_0107 (1.0%), and unique recombinant form (URF) (11.8%). Most URFs were the recombinants between CRF01_AE and CRF07_BC or CRF07_BC and CRF55_01B. Among the 93 subjects of antiretroviral therapy (ART)-naive, transmitted drug resistance against non-nucleoside reverse transcriptase inhibitors (NNRTIs) was 23.9%, of which V179D/E was the most frequent mutation, accounting for 18.2%. Among the 12 subjects of ART-experienced, drug resistance to first-line regimens developed severely.

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