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Genetic dissection of the degradation pathways for the mycotoxin fusaric acid in Burkholderia ambifaria T16

Authors
  • Vinacour, Matias
  • Moiana, Mauro
  • Forné, Ignasi
  • Jung, Kirsten
  • Bertea, Micaela
  • Calero Valdayo, Patricia M.
  • Nikel, Pablo I.
  • Imhof, Axel
  • Palumbo, Miranda C.
  • Fernández Do Porto, Dario
  • Ruiz, Jimena A.
Type
Published Article
Journal
Applied and Environmental Microbiology
Publisher
American Society for Microbiology
Publication Date
Dec 06, 2023
Volume
89
Issue
12
Identifiers
DOI: 10.1128/aem.00630-23
Source
ASM Journals
Keywords
License
Yellow

Abstract

Fusaric acid (FA) is an important virulence factor produced by several Fusarium species. These fungi are responsible for wilt and rot diseases in a diverse range of crops. FA is toxic for animals, humans and soil-borne microorganisms. This mycotoxin reduces the survival and competition abilities of bacterial species able to antagonize Fusarium spp., due to its negative effects on viability and the production of antibiotics effective against these fungi. FA biodegradation is not a common characteristic among bacteria, and the determinants of FA catabolism have not been identified so far in any microorganism. In this study, we identified genes, enzymes, and metabolic pathways involved in the degradation of FA in the soil bacterium Burkholderia ambifaria T16. Our results provide insights into the catabolism of a pyridine-derivative involved in plant pathogenesis by a rhizosphere bacterium.

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