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Genetic determinants of type 1 diabetes across populations.

Authors
  • Jahromi, Mohamed M
  • Eisenbarth, George S
Type
Published Article
Journal
Annals of the New York Academy of Sciences
Publication Date
Oct 01, 2006
Volume
1079
Pages
289–299
Identifiers
PMID: 17130568
Source
Medline
License
Unknown

Abstract

T1D results from autoimmune-mediated destruction of the pancreatic beta cells, a process that is conditioned by multiple genes and environmental factors. The main genetic determinants map to the major histocompatibility complex (MHC), and in particular DR and DQ, although, genes outside the MHC contribute, including the insulin gene, PTPN22, and CTLA-4. There are remarkable differences in genetic susceptibility to T1D between populations. We believe this variation reflects differing frequencies of diabetes causative and protective alleles and haplotypes, and thus remains a major genetic influence linked to the MHC region not accounted for by DR and DQ alleles. In this article, we discuss global variations in genetic susceptibility to T1D in view of current genetic understanding.

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