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Genetic counseling and predictive testing for colorectal cancer risk.

Authors
  • Petersen, G M
Type
Published Article
Journal
International journal of cancer. Journal international du cancer
Publication Date
Feb 20, 1996
Volume
69
Issue
1
Pages
53–54
Identifiers
PMID: 8600062
Source
Medline
License
Unknown

Abstract

In contrast to our rapidly increasing knowledge of the genetic basis of colorectal cancer and new molecular technologies, we are only in the early stages of characterizing the impact that this information will have on patients, their families and society. From our research and clinical experience with hereditary colorectal cancer syndromes, we have developed a framework for risk assessment that includes criteria for identifying those at higher genetic risk and guidelines for genetic counseling, predictive genetic testing and follow-up management. More research is needed to optimally translate this framework into wider clinical practice, including characterizing genetic heterogeneity and phenotype correlations, documenting the efficacy of screening and surgical interventions, and maximizing the awareness of health professionals on genetic counseling and the promise and limitations of gene tests.

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