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Genetic controls of susceptibility and resistance to 4-nitroquinoline 1-oxide-induced tongue carcinomas in rats.

Authors
  • Kitano, M1
  • Hirayama, Y
  • Tanuma, J
  • Matsuuchi, H
  • Miura, Y
  • Li, T J
  • Semba, I
  • Ozaki, H S
  • Kokubu, T
  • Hatano, H
  • Tada, M
  • Kobayashi, Y
  • Shisa, H
  • 1 Department of Oral Pathology, Kagoshima University Dental School, Sakuragaoka.
Type
Published Article
Journal
Japanese journal of cancer research : Gann
Publication Date
Nov 01, 1996
Volume
87
Issue
11
Pages
1097–1101
Identifiers
PMID: 9045935
Source
Medline
License
Unknown

Abstract

We analyzed the incidence of infiltrative mass-type tongue carcinomas (IMTC) induced in 550 rats by continuous oral administration of 0.001% 4-nitroquinoline 1-oxide solution for 180 days. The study included various crosses of susceptible Dark-Agouti rats (DA) and resistant Wistar/Furth rats (WF). DA showed a 93.6% incidence of IMTC measuring more than 5 mm in their largest diameter, while WF showed only a 4% incidence. Reciprocal F1 and F2 hybrids mated by DA and WF showed 47.5% and 45.8% incidences, respectively. Meanwhile, reciprocal backcrossed hybrids to DA and WF showed 73.7%, and 24.6% incidences, respectively. Segregation of the incidences suggests that there are two autosomal dominant genes, one linked to the susceptibility of DA and the other to the resistance of WF.

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