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Genetic characterization of novel reassortant H5N6-subtype influenza viruses isolated from cats in eastern China

Authors
  • Cao, Xueliang1, 2
  • Yang, Fan3
  • Wu, Haibo3
  • Xu, Lihua1
  • 1 Zhejiang Academy of Agricultural Science, Animal Husbandry and Veterinary Institute, 198 Shiqiao Road, Hangzhou, Zhejiang, 310021, China , Hangzhou (China)
  • 2 Dezhou College, Dezhou, Shandong, 253023, China , Dezhou (China)
  • 3 Zhejiang University, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, The First Affiliated Hospital, 79 Qingchun Road, Hangzhou, Zhejiang, 310003, China , Hangzhou (China)
Type
Published Article
Journal
Archives of Virology
Publisher
Springer-Verlag
Publication Date
Jul 21, 2017
Volume
162
Issue
11
Pages
3501–3505
Identifiers
DOI: 10.1007/s00705-017-3490-2
Source
Springer Nature
Keywords
License
Yellow

Abstract

Cats are susceptible to influenza A viruses and therefore may act as transmission vectors within households, posing a potential public health concern. Two novel reassortant H5N6 influenza viruses were isolated from cats in Zhejiang Province, Eastern China, in 2016. Both viruses were characterized by whole-genome sequencing with subsequent phylogenetic analysis and genetic comparison. Phylogenetic analysis showed that these viruses received their genes from H5N6, H9N2, and H7N9 influenza viruses isolated from China. These H5N6 viruses were able to replicate in mice without prior adaptation. Our results show that continued circulation of these viruses could endanger humans.

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