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Genetic Characteristics of HIV-1 CRF12_BF First Identified in Guangdong Province, China.

Authors
  • Lan, Yun1
  • He, Xiang2
  • Xin, Ruolei3
  • Li, Linghua1
  • Huang, Xuhe2
  • Deng, Xizi1
  • Tang, Xiaoping1
  • Jia, Weidong1
  • Cai, Weiping1
  • Hu, Fengyu1
  • 1 Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China. , (China)
  • 2 Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. , (China)
  • 3 Institute of AIDS/STD Prevention and Control, Beijing Center for Disease Prevention and Control, Beijing, China. , (China)
Type
Published Article
Journal
AIDS Research and Human Retroviruses
Publisher
Mary Ann Liebert
Publication Date
Feb 01, 2021
Volume
37
Issue
2
Pages
157–161
Identifiers
DOI: 10.1089/AID.2020.0193
PMID: 32873064
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Multiple HIV-1 genotypes were found circulating in Guangdong Province, China, as this province is located in South China and has a high frequency of international trade. In this study, we report the near full-length genome (NFLG) of CRF12_BF that was identified from a male patient in Guangzhou city, Guangdong Province; this is the first time CRF12_BF has been reported in mainland China. The NFLG was amplified, and then PCR products were sequenced by Sanger sequencing. The CRF12_BF strain was confirmed by the Basic Local Alignment Search Tool and a neighbor-joining phylogenetic tree. In addition, this CRF12_BF strain was confirmed to contain the non-nucleoside reverse transcriptase inhibitor mutation E138A associated with potential low-level resistance against efavirenz and low-level resistance against rilpivirine by the Stanford University HIV Drug Resistance Database program. The analyzed sequence data in this study will provide more information on the HIV epidemic in China.

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