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Genetic association of the HLA DRB1 gene locus on chromosome 6p21.3 with schizophrenia.

Authors
  • Wright, P
  • Donaldson, P T
  • Underhill, J A
  • Choudhuri, K
  • Doherty, D G
  • Murray, R M
Type
Published Article
Journal
The American journal of psychiatry
Publication Date
Dec 01, 1996
Volume
153
Issue
12
Pages
1530–1533
Identifiers
PMID: 8942447
Source
Medline
License
Unknown

Abstract

DRB1*04 alleles may partially account for the genetic predisposition to schizophrenia. The association reported here may be explained by genetic linkage or by an autoimmune pathophysiology for a proportion of schizophrenia cases. Alternatively, it may be that maternal B lymphocytes that do not express the DR4 antigen encoded by DRB1*04 respond to influenza virus by producing antibodies that perturb neurodevelopment, thus underpinning a proportion of schizophrenia cases.

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