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Genes Encoding GABA-β and HT1D Receptors in Bipolar I (Manic Phase) Patients.

Authors
  • Moradi, Mohammadreza1
  • Saidijam, Massoud1
  • Yadegarazari, Reza1
  • Jahangard, Leila2
  • Seifi, Maryam1
  • Matinnia, Nasrin3
  • Ghaleiha, Ali2
  • 1 Molecular Medicine Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. , (Iran)
  • 2 Behavioral Disorders and Substance Abuse Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. , (Iran)
  • 3 Department of Nursing, Faculty of Science, Hamadan Branch, Islamic Azad University, Hamadan, Iran. , (Iran)
Type
Published Article
Journal
Basic and clinical neuroscience
Publication Date
Jan 01, 2018
Volume
9
Issue
2
Pages
129–134
Identifiers
DOI: 10.29252/NIRP.BCN.9.2.129
PMID: 29967672
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

According to the cumulative evidence, genes encoding GABA receptors inhibit neurotransmitters in CNS and are intricately involved in the pathogenesis of mood disorders. Based on this hypothesis, these genes may be expressed in bipolar patients. As a result, we evaluated the gene expressions of GABA-β3 and HT1D receptors to assess their associations with bipolar mood disorder. In this study, 22 patients with bipolar I disorder (single manic episode) and 22 healthy individuals were enrolled. All participants were older than 15 years and had referred to Farshchian Hospital, Hamadan, Iran. They were diagnosed based on DSM IV-TR criteria and young mania rating scale in order to determine the severity of mania by a psychiatrist as bipolar Type 1 disorder in manic episode. We evaluated the expression of GABA-β3 and HT1D receptor genes in peripheral blood mononuclear cells, using real-time RT-PCR analysis. In our study, a reduction in the gene expression of GABA-β3 and HT1D receptors was observed in peripheral blood mononuclear cells of the patients with bipolar disorders compared to the healthy controls. The results of this study supports the hypothesis that the gene expression for serotonin and GABA receptors can be employed in elucidating the pathogenesis of bipolar disorders.

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