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The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes.

Authors
  • Virtaneva, K I
  • Angelisová, P
  • Baumruker, T
  • Horejsí, V
  • Nevanlinna, H
  • Schröder, J
Type
Published Article
Journal
Immunogenetics
Publication Date
Jan 01, 1993
Volume
37
Issue
6
Pages
461–465
Identifiers
PMID: 8436422
Source
Medline
License
Unknown

Abstract

CD37, CD53, and R2 leukocyte surface antigens are members of a novel family of structurally related proteins. They all have four transmembrane-spanning domains with a single major extracellular loop. The CD37 is expressed on B cells and on a subpopulation of T cells. The CD53 is known as a panleukocyte marker. The R2 protein is an activation antigen of T cells. The CD37, CD53, and R2 genes were assigned with the help of human/rodent somatic cell hybrids and human-specific probes to human chromosomes 19, 1, and 11, respectively. For the regional assignment, various deletion hybrids were used to map CD37 to 19p13-q13.4, CD53 to 1p12-p31, and R2 to 11p12.

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